Crime Scene Re-investigation: A Postmortem Analysis of Game Account Stealers' Behaviors

As item trading becomes more popular, users can change their game items or money into real money more easily. At the same time, hackers turn their eyes on stealing other users game items or money because it is much easier to earn money than traditional gold-farming by running game bots. Game companies provide various security measures to block account- theft attempts, but many security measures on the user-side are disregarded by users because of lack of usability. In this study, we propose a server-side account theft detection system base on action sequence analysis to protect game users from malicious hackers. We tested this system in the real Massively Multiplayer Online Role Playing Game (MMORPG). By analyzing users full game play log, our system can find the particular action sequences of hackers with high accuracy. Also, we can trace where the victim accounts stolen money goes.Comment: 7 pages, 8 figures, In Proceedings of the 15th Annual Workshop on Network and Systems Support for Games (NetGames 2017

Functional characterization of a zinc finger protein AEBP2

AEBP2 is a zinc finger protein that has been shown to interact with the mammalian Polycomb Repression Complex 2 (PRC2). I characterized this unknown protein and tested its potential targeting roles for the PRC2. AEBP2 is an evolutionarily well-conserved gene that is found in animals ranging from flying insects to mammals. The transcription of mammalian AEBP2 is driven by two alternative promoters and produces multiple transcripts that give rise to at least two isoforms of the protein. These isoforms show developmental stage-specific expression patterns: the larger adult-specific form (52 kDa) and the smaller embryo-specific form (31 kDa). The AEBP2 protein binds to a DNA-binding motif with an unusual bipartite structure, CTT(N)15-23cagGCC with lower-case base pairs being less critical. A large fraction of AEBP2\u27s target loci also map closely to the known target loci of the PRC2. In fact, many of these loci are co-occupied by the two proteins, AEBP2 and SUZ12. This suggests that AEBP2 is most likely a targeting protein for the mammalian PRC2 complex. To investigate the in vivo roles of this protein, a mutant mouse line with disrupted Aebp2 transcription has been generated. Breeding experiments demonstrated embryonic lethality in the Aebp2-mutant homozygotes, but survival of the heterozygotes to adulthood with fertility. In developing mouse embryos, Aebp2 is expressed mainly within cells of neural crest origin, such as the dorsal root ganglia, and facial cartilages and bones. In addition, many heterozygotes display a set of phenotypes, including enlarged colon and hypopigmentation, similar to those observed in human patients with Hirschsprung’s disease and Waardenburg syndrome. These phenotypes are caused by the absence of the neural crest-derived ganglia in hindguts and melanocytes. Additional analyses further confirmed changes in the expression and methylation levels of H3K27me3 on the genes involved in the development of the neural crest cells in the Aebp2 heterozygotes. Overall, these results suggest that Aebp2 may regulate the development of the neural crest cells through the PRC2-mediated epigenetic mechanism

Recruitment and biological consequences of histone modification of H3K27me3 and H3K9me3.

Two histone marks, H3K27me3 and H3K9me3, are well known for their repressive roles in the genic and nongenic regions of metazoan genomes. Several protein complexes are known to be responsible for generating these marks, including polycomb repression complex 2 and several H3K9 methylases. Recent studies have shown that the targeting of these histone-modifying complexes within mammalian genomes may be mediated through several DNA-binding proteins, including AEBP2, JARID2, and YY1. In this review, we discuss the potential targeting mechanisms in light of the recent results that have been derived from genome-wide chromatin immunoprecipitation sequencing data and the in vivo functions of these two histone marks in light of the results derived from mouse and human genetic studies

Multimodal animation control

Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.Includes bibliographical references (leaf 44).In this thesis, we present a multimodal animation control system. Our approach is based on a human-centric computing model proposed by Project Oxygen at MIT Laboratory for Computer Science. Our system allows the user to create and control animation in real time using the speech interface developed using SpeechBuilder. The user can also fall back to traditional input modes should the speech interface fail. We assume that the user has no prior knowledge and experience in animation and yet enable him to create interesting and meaningful animation naturally and fluently. We argue that our system can be used in a number of applications ranging from PowerPoint presentations to simulations to children's storytelling tools.by Hana Kim.M.Eng

A Compendium of Core Lexicon Checklists

Core Lexicon (CoreLex) is a relatively new approach assessing lexical use in discourse. CoreLex examines the specific lexical items used to tell a story, or how typical lexical items are compared with a normative sample. This method has great potential for clinical utilization because CoreLex measures are fast, easy to administer, and correlate with microlinguistic and macrolinguistic discourse measures. The purpose of this article is to provide clinicians with a centralized resource for currently available CoreLex checklists, including information regarding development, norms, and guidelines for use

Sexual differences of imprinted genes\u27 expression levels

In mammals, genomic imprinting has evolved as a dosage-controlling mechanism for a subset of genes that play critical roles in their unusual reproduction scheme involving viviparity and placentation. As such, many imprinted genes are highly expressed in sex-specific reproductive organs. In the current study, we sought to test whether imprinted genes are differentially expressed between the two sexes. According to the results, the expression levels of the following genes differ between the two sexes of mice: Peg3, Zim1, Igf2, H19 and Zac1. The expression levels of these imprinted genes are usually greater in males than in females. This bias is most obvious in the developing brains of 14.5-dpc embryos, but also detected in the brains of postnatal-stage mice. However, this sexual bias is not obvious in 10.5-dpc embryos, a developmental stage before the sexual differentiation. Thus, the sexual bias observed in the imprinted genes is most likely attributable by gonadal hormones rather than by sex chromosome complement. Overall, the results indicate that several imprinted genes are sexually different in terms of their expression levels, and further suggest that the transcriptional regulation of these imprinted genes may be influenced by unknown mechanisms associated with sexual differentiation. © 2013 Elsevier B.V

Inversion of the imprinting control region of the Peg3 domain

© 2017 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The imprinting of the mouse Peg3 domain is controlled through a 4-kb genomic region encompassing the bidirectional promoter and 1st exons of Peg3 and Usp29. In the current study, this ICR was inverted to test its orientation dependency for the transcriptional and imprinting control of the Peg3 domain. The inversion resulted in the exchange of promoters and 1st exons between Peg3 and Usp29. Paternal transmission of this inversion caused 10-fold down-regulation of Peg3 and 2-fold up-regulation of Usp29 in neonatal heads, consistent with its original promoter strength in each direction. The paternal transmission also resulted in reduced body size among the animals, which was likely contributed by the dramatic down-regulation of Peg3. Transmission through either allele caused no changes in the DNA methylation and imprinting status of the Peg3 domain except that Zfp264 became bi-allelic through the maternal transmission. Overall, the current study suggests that the orientation of the Peg3-ICR may play no role in its allele-specific DNA methylation, but very critical for the transcriptional regulation of the entire imprinted domain

Simple proofs of open problems about the structure of involutions in the Riordan group

AbstractWe prove that if D=(g(x),f(x)) is an element of order 2 in the Riordan group then g(x)=±exp[Φ(x,xf(x)] for some antisymmetric function Φ(x,z). Also we prove that every element of order 2 in the Riordan group can be written as BMB-1 for some element B and M=(1,-1) in the Riordan group. These proofs provide solutions to two open problems presented by L. Shapiro [L.W. Shapiro, Some open questions about random walks, involutions, limiting distributions and generating functions, Adv. Appl. Math. 27 (2001) 585–596]